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Kegg Shikimic Acid


What is Shikimic Acid?

Shikimic acid is a white crystal compound of nonnitrogenous acid found in various plants naturally.Shikimic acid has two kind functional groups in the same molecule, three hydroxyl groups and a carboxylic acid group, which are optically active. They can yield various kinds of esters and salts.

The most important feature of cyclitol is that there are chiral isomers, key intermediates in the biosynthesis of aromatic compounds in living metabolism. Shikimic acid is a key intermediate in the biochemical pathway from phosphoenolpyruvic acid to tyrosine.Shikimic acid is a precursor of many alkaloids, aromatic amino acids, and indole derivatives. Shikimic acid is widely used as a chiral building block for the synthesis of pharmaceuticals.

English nickname:

3,4,5-Trihydroxy-1-cyclohexene-1-carboxylic acid; Shikimicacid; 97%; (3R,4S,5R)-3,4,5-trihydroxycyclohex-1-enecarboxylic acid; (-)-Shikimic acid; Kava Kava Extract


Details of parameters

Product Name: Shikimic acid
Synonyms: Kava root   extract;L-SHIKIMIC ACID
CAS: 138-59-0
MF: C7H10O5
MW: 174.15
EINECS: 205-334-2
Product Categories: Natural Plant   Extract;API
Mol File: 138-59-0.mol

1. Properties: Colorless or white acicular crystal.

2. Solubility: in 20 ° C water solubility is 18%, slightly soluble in ethanol, ether, almost insoluble in chloroform, benzene.

Boiling point (° C) : 400.5

4. Melting point (° C) : 185~187

5. Flash point (° C) : 210.1

6. Relative density (D204) : 1.725


Identification The main peak   retention time of the reference solution is the same as the main peak   retention time of the sample solution. Complies HPLC
Description White to   off-white powder, no visible foreign matter Off-white   powder, no visible foreign matter CP2015
Odor& Taste Odorless or   slightly sour Odorless CP2015
Specific rotation -175~ -184 -183.6 CP2015
Assay on a dry basis) ≥98.0% 99.20% CP2015
Moisture ≤1.0% 0.10% CP2015
Ash ≤0.8% 0.10% CP2015
Heavy metals ≤20mg/kg <20mg/kg CP2015
Melting point 175~190℃ 186.4℃-186.7℃ CP2015


Pharmacological effects: 

Shikimic acid is a monomer compound extracted from star anise, which has anti-inflammatory and analgesic effects and is an anticancer drug intermediate.Shikimic acid inhibits platelet aggregation, venous thrombosis and cerebral thrombosis by affecting arachidonic acid metabolism. Shikimic acid has anti-inflammatory and analgesic effects, and can also be used as an antiviral and anti-cancer drug intermediate.

Star anise contains shikimic acid, an important component against Asian bird flu virus.Experts say it is the world's only weapon against bird flu.Native to China and Vietnam, it is the fruit of a small Oriental tree of the Magnolia family. It has a pungent, licorice like taste. It is a traditional condiment in Oriental cooking and a major spice in French liqueur, such as green anisette and anisette.It can also be used to enhance the flavor of candy, ouzo and tobacco.The medicinal properties of star anise had already attracted attention before bird flu, including its possible anti-cancer properties.Star anise has gained renewed attention as a major source of shikimic acid, an important component of the drug Tamiflu, which is effective against the deadly H5N1 bird flu virus."It takes 10 Tamiflu capsules to treat a person infected with bird flu and 13 grams of star anise to make 10 Tamiflu capsules," said Albert Elgrisi, director of anise-wine maker Ricca in Marseille, France.


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